Journal
MOLECULAR BRAIN RESEARCH
Volume 86, Issue 1-2, Pages 145-152Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0169-328X(00)00279-5
Keywords
neurotensin; cold water swim stress; medial preoptic area; lateral hypothalamus; in situ hybridization
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Funding
- NINDS NIH HHS [NS20643] Funding Source: Medline
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Stress-induced analgesia is a well-documented phenomenon that occurs in all mammalian species. Forced cold water swim produces a type of stress-induced analgesia that is independent of mu opioid receptors. The neuropeptide neurotensin (NT) has been implicated in mu opioid-independent analgesia (MOIA), but the circuitry of this system is largely unknown. The medial preoptic area (MPO) and lateral hypothalamus (LH) are two regions that are known to modulate pain processing. These two regions also contain neurotensinergic projections to the periaqueductal gray, a region that has been shown to produce MOIA upon injection of NT. The goal of this study was to determine if cold water swim (CWS) stress, which produces MOIA, activates the NT-ergic systems in these two regions. In situ hybridization results indicate that CWS increases the level of NT mRNA within neurons in the MPO and LH, suggesting that these two regions are activated during this process. (C) 2001 Elsevier Science B.V. All rights reserved.
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