Journal
BIOCHIMIE
Volume 92, Issue 2, Pages 121-127Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2009.10.007
Keywords
DNA; Nanodevices; Tweezers; I-motif; G-quadruplex
Categories
Funding
- National Natural Science Foundation of China [20831003, 90813001, 20833006]
- CAS
- Jilin Province
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A novel multi-functional, proton-fueled DNA tweezers has been constructed. Starting from simple conformation change of i-motif DNA, the nanodevice can accomplish movements such as repeatedly capture or release target DNA and protein. The DNA tweezers, driven by the solution pH without the need of injecting external energy, are robust and highly reversible with the responses of 1-2 orders of magnitude faster than the DNA-fueled machine, and does not accumulate duplex waste products to poison the system. Our work has demonstrated the successful combination of the operating principles of DNA-based nanomechanical device with the unique molecular recognition properties of DNA, which we believed could open an exciting avenue in the design and construction of easy-to-handle, cost-efficient, reliable and high efficient functional nanostructure. (C) 2009 Elsevier Masson SAS. All rights reserved.
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