Journal
BIOCHIMIE
Volume 91, Issue 1, Pages 19-29Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2008.05.015
Keywords
Lactoferrin; Antibacterial; Antiviral; Antifungal; Antiparasitic
Categories
Funding
- Canadian Institutes of Health Research
- Canada Research Chair
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Milk is a vital nutritional source for the offspring of all mammals, including humans. In addition to its nutritional value, it is a rich source of proteins including lactoferrin. Lactoferrin is a truly multifunctional protein that has been studied extensively over the past decades. It is best known for its ability to bind iron, which eventually led to the discovery of its antibacterial activity. In addition, lactoferrin has demonstrated potent antiviral, antifungal and antiparasitic activity, towards a broad spectrum of species. It is also considered to be an important host defense molecule during infant development. In this review, we focus on the antimicrobial activities of lactoferrin with particular emphasis on antibacterial and antiviral activities, although its antifungal and -parasitic activity are also discussed. (C) 2008 Elsevier Masson SAS. All fights reserved.
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