Journal
BIOCHIMIE
Volume 91, Issue 10, Pages 1307-1310Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2009.07.001
Keywords
Hypoxia; c-Myc; Acetylation; Histone H4
Categories
Funding
- NCI NIH HHS [P30 CA016087-280003, P30 CA016087, CA16087] Funding Source: Medline
- NIEHS NIH HHS [R01 ES014454, ES014454, ES005512, R01 ES005512, R01 ES005512-17, R01 ES014454-03, P30 ES000260-44, ES000260, P30 ES000260] Funding Source: Medline
Ask authors/readers for more resources
Global acetylation of histone H4 is a mark of gene transcriptional activation. The c-Myc transcription factor binds to specific DNA sites in cellular chromatin and induces the acetylation of histone H4. In this study, hypoxia (1% Oxygen) induced a decrease in both global acetylated histone H4 (AcH4) and c-Myc in human lung carcinoma A549 cells and in human bronchial epithelial Beas-2B cells, The decline was more striking in A549 cells compared to Beas2-B cells, when cells were exposed to hypoxic stress for 24 h. Further studies showed that these alterations of global AcH4 can be attributed to the decrease in c-Myc protein levels. While hypoxia-induced gene activation is known to be mediated by Hypoxia Response Elements (HRE), the mechanism for down-regulation of genes by hypoxia is not known. The decrease in c-Myc protein levels induced by hypoxia may contribute to hypoxia-induced gene repression. (C) 2009 Elsevier Masson SAS. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available