Journal
BIOCHIMIE
Volume 91, Issue 3, Pages 320-328Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2008.10.010
Keywords
Ras; p120-RasGAP; SH2 domain; SH3 domain
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Funding
- Ligue Nationale Contre le Cancer
- Ministere de la Technologic et de la Recherche [021-0521]
- Franco-Thai program
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p120-RasGAP (Ras GTPase activating protein) plays a key role in the regulation of Ras-GTP bound by promoting GTP hydrolysis via its C-terminal catalytic domain. The p120-RasGAP N-terminal part contains two SH2, SH3, PH (pleckstrin homology) and CaLB/C2 (calcium-dependent phospholipid-binding domain) domains. These protein domains allow various functions, such as anti-/pro-apoptosis, proliferation and also cell migration depending of their distinct partners. The p120-RasGAP domain participates in protein-protein interactions with Akt, Aurora or RhoGAP to regulate functions described bellow. Here, we summarize, in angiogenesis and cancer, the various functional roles played by p120-RasGAP domains and their effector partners in downstream signaling. (C) 2008 Elsevier Masson SAS. All fights reserved.
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