Journal
BIOCHIMIE
Volume 91, Issue 8, Pages 1053-1057Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2009.04.019
Keywords
CYP7A1; H-1 NMR spectroscopy; MCP-1; Metabonomics; Taurine
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Funding
- Fondo de Investigacion Sanitaria (FIS) [05/1606]
- CIBERDEM
- Generalitat de Catalunya [FI-G 0503]
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Monocyte chemoattractant protein-1 (MCP-1) plays a relevant role in macrophage migration but recent findings suggest an additional role in lipid and glucose metabolism. We report the use of H-1 NMR spectroscopy as a useful complementary method to assess the metabolic function of this gene in a comparative strategy. This metabonomic analysis was rapid, simple, quantitative and reproducible, and revealed a suggestive relationship between the expression of the MCP-1 gene and hepatic glucose and taurine concentrations. This approach should be considered in genetically modified mice when a metabolic alteration is suspected, or in routine assessment of metabolic phenotype. (C) 2009 Elsevier Masson SAS. All rights reserved.
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