Journal
BIOCHIMIE
Volume 90, Issue 8, Pages 1250-1263Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biochi.2008.02.013
Keywords
G-quadruplex; yeast; telomere; transcription; chromatin
Categories
Funding
- NIA NIH HHS [R01 AG021521, R01 AG021521-04, R01 AG021521-04S1, 5R01AG021521] Funding Source: Medline
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Certain guanine-rich sequences are capable of forming higher order structures known as G-quadruplexes. Moreover, particular genomic regions in a number of highly divergent organisms are enriched for such sequences, raising the possibility that G-quadruplexes form in vivo and affect cellular processes. While G-quadruplexes have been rigorously studied in vitro, whether these structures actually form in vivo and what their roles might be in the context of the cell have remained largely unanswered questions. Recent studies suggest that G-quadruplexes participate in the regulation of such varied processes as telomere maintenance, transcriptional regulation and ribosome biogenesis. Here we review studies aimed at elucidating the in vivo functions of quadruplex structures, with a particular focus on findings in yeast. In addition, we discuss the utility of yeast model systems in the study of the cellular roles of G-quadruplexes. (C) 2008 Elsevier Masson SAS. All rights reserved.
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