Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1845, Issue 2, Pages 232-247Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbcan.2014.01.008
Keywords
Malignant Mesothelioma; Erionite/SV40; p16(INK4a)/p(14ARF); NE2; PI3K/AKT; Genes and pathways
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Funding
- CAPES (Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior)
- Brazilian government through the Science without Borders program at the University of Montana
- CNPQ
- Fundacao de Amparo a Pesquisa do estado de Minas Gerais (FAPEMIG) [APQ 2112-10, APQ 00793-13]
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Malignant Mesothelioma (MM) is a very aggressive cancer with low survival rates and often diagnosed at an advanced stage. Several players have been implicated in the development of this cancer, such as asbestos, erionite and the simian virus 40 (SV40). Here, we have reviewed the involvement of erionite, SV40, as well as, the role of several genes p16(INK4a)/p14(ARF),NF2, LATS2, SAV, CTNNB1 and among others), the pathways (RAS, PI3K, Wnt, BCL and Hippo), and their respective roles in the development of MM. (C) 2014 Elsevier B.V. All rights reserved.
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