Journal
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY
Volume 47, Issue 2, Pages 207-210Publisher
OXFORD UNIV PRESS
DOI: 10.1093/jac/47.2.207
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A Klebsiella pneumoniae strain resistant to cefoxitin and oxyimino-cephalosporins was cultured from a child hospitalized in Paris, France, in 1992. This isolate harboured a beta -lactamase gene located on an approximately 200 kb non-self-transferable plasmid. The beta -lactamase identified, DHA-2, shared 99% amino acid identity with the AmpC enzyme of Morganella morganii. DHA-2 was a point-mutant derivative of DHA-I identified previously in a Salmonella enteritidis isolate. DHA-2 expression was inducible due to an ampR regulatory gene. This is the first report of an inducible and plasmid-located cephalosporinase from K. pneumoniae.
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