Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1846, Issue 2, Pages 485-493Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbcan.2014.09.006
Keywords
Semaphorin; Semaphorin 5A; Developmental biology; Cancer; Plexins; Neuropilins
Categories
Funding
- National Cancer Institute, National Institutes of Health [U54CA163120]
- Cancer Center Support Grant from the National Cancer Institute, National Institutes of Health [P30CA036727]
- University of Nebraska Medical Center fellowship
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The ultraprecise wiring of neurons banks on the instructions provided by guidance cue proteins that steer them to their appropriate target tissue during neuronal development. Semaphorins are one such family of proteins. Semaphorins are known to play major physiological roles during the development of various organs including the nervous, cardiovascular, and immune systems. Their role in different pathologies including cancer remains an intense area of investigation. This review focuses on a novel member of this family of proteins, semaphorin 5A, which is much less explored in comparison to its other affiliates. Recent reports suggest that semaphorins play important roles in the pathology of cancer by affecting angiogenesis, tumor growth and metastasis. We will firstly give a general overview of the semaphorin family and its receptors. Next, we discuss their roles in cellular movements and how that makes them a connecting link between the nervous system and cancer. Finally, we focus our discussion on semaphorin 5A to summarize the prevailing knowledge for this molecule in developmental biology and carcinogenesis. (C) 2014 Elsevier B.V. All rights reserved.
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