Journal
TRENDS IN PHARMACOLOGICAL SCIENCES
Volume 22, Issue 2, Pages 97-100Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0165-6147(00)01615-1
Keywords
-
Categories
Ask authors/readers for more resources
Most current assays used to quantitate the pharmacodynamic effect of anti-viral agents measure the net inhibitory effect of a drug on virus replication over several days in an in vitro cell culture. Such endpoint experiments give cumulative measures of inhibition that vary with the assay used and therefore provide suboptimal information on likely in vivo drug performance. We argue that instantaneous inhibition (proportion of cell infection prevented at a point in time) is a more robust pharmacodynamic measure, and propose techniques to estimate this quantity from endpoint data. Implications for the quantification of drug interactions are discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available