Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1826, Issue 1, Pages 209-214Publisher
ELSEVIER
DOI: 10.1016/j.bbcan.2012.04.004
Keywords
Cancer; adipose tissue; adipose progenitors; obesity; angiogenesis
Categories
Funding
- AIRC (Associazione Italiana per la Ricerca sul Cancro)
- Fondazione Umberto Veronesi
- Ministero della Salute
- American Cancer Society
- Cancer Prevention and Research Institute of Texas (CPRIT)
Ask authors/readers for more resources
Despite recent evidence of the cancer-promoting role of adipose tissue-derived progenitor and differentiated cells, the use of lipotransfer for tissue/organ reconstruction after surgical removal of cancer is increasing worldwide. Here we discuss in a multidisciplinary fashion the preclinical data connecting obesity, adipose cells and cancer progression, as well as the clinical data concerning safety of lipotransfer procedures in cancer patients. A roadmap towards a more rationale use of lipotransfer in oncology is urgently needed and should include preclinical studies to dissect the roles of different adipose tissue-derived cells, the evaluation of drugs currently candidate to inhibit the interaction between adipose and tumor cells, and carefully designed clinical trials to investigate the safety of lipotransfer procedures in cancer patients. (C) 2012 Elsevier B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available