Journal
BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER
Volume 1805, Issue 1, Pages 87-96Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbcan.2009.09.005
Keywords
Cancer; Angiogenesis; miRNA; Endothelial cell
Categories
Funding
- Dutch Cancer Society [UM2008-4101, VU2009-4358]
- VLT
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Tumor angiogenesis facilitates tumor metastasis and allows malignant tissues to grow beyond a diffusion limited size. It is a complex process that requires endothelial cells to execute specific steps during different phases. miRNAs are small non-coding RNAs that act as molecular switches to redirect the expression profile of a cell. Evidence is emerging that miRNAs are important players in endothelial cell biology and tumor angiogenesis. In this review we summarize the available data of miRNA expression in the endothelium. In addition, we describe the current knowledge regarding the function of miRNAs in endothelial cell biology. Finally, we discuss the potential applications of miRNA based treatment strategies in angiostatic cancer therapy. (C) 2009 Elsevier B.V. All rights reserved.
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