Journal
JOURNAL OF VIROLOGY
Volume 75, Issue 3, Pages 1301-1311Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/JVI.75.3.1301-1311.2001
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Funding
- NIAID NIH HHS [U19 AI38584, U01 AI038858, R37 AI028568, U01 AI041531, R01 AI040873, AI38858, R01 AI044656, U01 AI048023, N01AI95362, AI39966, R01 AI039966] Funding Source: Medline
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Virus-specific cytotoxic T-lymphocyte (CTL) responses are critical in the control of human immunodeficiency virus type 1 (HIV-1) infection and will play an important part in therapeutic and prophylactic HIV-1 vaccines. The identification of virus specific epitopes that are efficiently recognized by CTL is the first step in the development of future vaccines. Here we describe the immunological characterization of a number of novel HIV-1-specific, HLA-A2-restricted CTL epitopes that share a high degree of conservation within HIV-1 and a strong binding to different alleles of the HLA-A2 superfamily. These novel epitopes include the first reported CTL epitope in the Vpr protein. Two of the novel epitopes were immunodominant among the HLA-A2-restricted CTL responses of individuals with acute and chronic HIV-1 infection. The novel CTL epitopes identified here should be included in future vaccines designed to induce HIV-1-specific CTL responses restricted by the HLA-A2 superfamily and will be important to assess in immunogenicity studies in infected persons and in uninfected recipients of candidate HIV-1 vaccines.
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