Journal
NEURON
Volume 29, Issue 2, Pages 353-366Publisher
CELL PRESS
DOI: 10.1016/S0896-6273(01)00211-2
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Funding
- NIMH NIH HHS [K02 MH01046] Funding Source: Medline
- NINDS NIH HHS [R01 NS34661, NS01973] Funding Source: Medline
- Telethon [F.2] Funding Source: Medline
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During corticogenesis, early-born neurons of the pre-plate and layer 6 are important for guiding subsequent neuronal migrations and axonal projections. Tbr1 is a putative transcription factor that is highly expressed in glutamatergic early-born cortical neurons. In Tbr1-deficient mice, these early-born neurons had molecular and functional defects. Cajal-Retzius cells expressed decreased levels of Reelin, resulting in a reeler-like cortical migration disorder. Impaired subplate differentiation was associated with ectopic projection of thalamocortical fibers into the basal telencephalon. Layer 6 defects contributed to errors in the thalamocortical, corticothalamic, and callosal projections. These results show that Tbr1 is a common genetic determinant for the differentiation of early-born glutamatergic neocortical neurons and provide insights into the functions of these neurons as regulators of cortical development.
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