Journal
BIOTECHNOLOGY LETTERS
Volume 23, Issue 3, Pages 169-173Publisher
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1005636121060
Keywords
bacterial epoxide hydrolase; pH-optimization; Rhodococcus ruber; temperature-optimization
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The epoxide hydrolase-catalyzed resolution of (+/-)-2-methylglycidyl benzyl ether, a versatile chiral building block for the asymmetric synthesis of bioactive compounds, mediated by whole cells of Rhodococcus ruber SM 1789 was accomplished. Among various parameters (such as temperature, buffer type, pH and catalyst/substrate-ratio) an elevated substrate-concentration proved to be particularly sensitive with respect to a significant enhancement of the enantioselectivity.
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