Journal
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Volume 1844, Issue 1, Pages 191-197Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2013.08.002
Keywords
MicroRNA; miRNA family; Cancer therapy
Categories
Funding
- Natural Science Foundation of China [61001013, 31271405, 61370010, 61001143, 81101115]
- Fundamental Research Funds for the Central Universities [2010121084, 2010121061]
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MicroRNAs (miRNAs) are endogenous, short, non-coding RNA molecules that are directly involved in the post-transcriptional regulation of gene expression. Dysregulation of miRNAs is usually associated with diseases. Since miRNAs in a family intend to have common functional characteristics, proper assignment of miRNA family becomes heuristic for better understanding of miRNA nature and their potentials in clinic. In this review, we will briefly discuss the recent progress in miRNA research, particularly its impact on protein and its clinical application in cancer research in a view of miRNA family. This article is part of a Special Issue entitled: Computational Proteomics, Systems Biology & Clinical Implications. Guest Editor: Yudong Cai. (C) 2013 Elsevier B.V. All rights reserved.
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