Journal
JAPANESE JOURNAL OF PHARMACOLOGY
Volume 85, Issue 2, Pages 203-206Publisher
JAPANESE PHARMACOLOGICAL SOC
DOI: 10.1254/jjp.85.203
Keywords
hypercholesterolemia; renal artery; endothelium-derived hyperpolarizing factor
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The tension of isolated rings was measured isometrically to compare the N-G-nitro-L-arginine- and indomethacin-resistant relaxation by acetylcholine (ACh) in the renal artery from normal rabbits and short term hypercholesterolemia rabbits (0.5% cholesterol chow for 5 weeks). ACh-induced relaxation in the renal artery precontracted with phenylephrine was not influenced by cholesterol-enriched chow. However, in comparison with artery from normal rabbits, the N-G-nitro-L-arginine- and indomethacin-resistant endothelium-dependent relaxation by ACh was significantly enhanced by the chow. The resistant part of ACh-induced relaxation was significantly inhibited when the artery was treated with tetraethylammonium or SKF 525a. Results suggest that short term hypercholesterolemia modulates endothelium-derived hyperpolarizing factor-mediated relaxation in rabbit renal artery.
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