Journal
BRITISH JOURNAL OF HAEMATOLOGY
Volume 112, Issue 2, Pages 466-468Publisher
BLACKWELL SCIENCE LTD
DOI: 10.1046/j.1365-2141.2001.02524.x
Keywords
fetal thrombopoiesis; reticulated platelets; thrombopoietin; glycocalicin
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To characterize fetal thrombopoiesis, we determined plasma thrombopoietin (TPO) and glycocalicin levels, platelet counts and reticulated platelets (RP) of fetuses and compared them with the respective values of their mothers. Percutaneous umbilical vein sampling in abnormal pregnancies revealed twofold higher thrombopoietin levels and 20-fold higher reticulated platelet counts, but lower levels of glycocalicin in fetuses compared with their mothers (P < 0.05). Neither the expression of platelet glycoprotein Ib and IIb on platelets nor the platelet counts were different between mothers and their fetuses. These data indicate enhanced thrombopoiesis and/or increased platelet turnover in fetuses.
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