Journal
MICROBES AND INFECTION
Volume 3, Issue 2, Pages 109-119Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S1286-4579(00)01358-7
Keywords
monocyte; interleukin 12; complement
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Funding
- NHLBI NIH HHS [HL58527] Funding Source: Medline
- NIAID NIH HHS [AI40507, AI01223] Funding Source: Medline
- NIDCR NIH HHS [DE12167] Funding Source: Medline
- NIEHS NIH HHS [ES09606] Funding Source: Medline
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Interleukin 12 (IL-12) is central to the orchestration of cell-mediated immune responses in the innate as well as the adaptive immune system. Recent studies of the pathogenesis of diseases as disparate as measles and asthma have suggested that the complement system, itself at the interface of innate and adaptive immunity, is a biologically relevant regulator of IL-12 production. These data are reviewed here. (C) 2001 Editions scientifiques et medicales Elsevier SAS.
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