Journal
BONE MARROW TRANSPLANTATION
Volume 27, Issue 3, Pages 235-239Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.bmt.1702791
Keywords
human bone marrow; stroma; hematopoietic progenitor cells; stem cells; mesenchymal stem cells; allogeneic and autologous transplantation
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In recent Sears, there has been an increasing interest in non-hematopoietic pluripotent progenitor cells that are found in the bone marrow. Mesenchymal stem cells (MSCs) are the first non-hematopoietic progenitors to be isolated from the bone marrow and extensively characterized. In addition to their ability to support hematopoiesis, MSCs can differentiate into osteocytes, chondrocytes, tenocytes, adipocytes and smooth muscle cells, This article will review our current understanding of bone marrow stroma and MSCs and their potential therapeutic role in the setting of hematopoietic stem cell transplantation.
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