Journal
MEMORIAS DO INSTITUTO OSWALDO CRUZ
Volume 96, Issue 2, Pages 229-232Publisher
FUNDACO OSWALDO CRUZ
DOI: 10.1590/S0074-02762001000200015
Keywords
dengue; cytokines; dengue hemorrhagic fever
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Pro-inflammatory cytokines are believed to play an important role in the pathogenesis of dengue infection. This study reports cytokine levels in a total of 54 patients examined in Recife, State of Pernambuco, Brazil. Five out of eight patients who had hemorrhagic manifestations presented tumor necrosis factor-alpha (TNF-alpha) levels in sera which were statistically higher than those recorded for controls. In contrast, only one out of 16 patients with mild manifestations had elevated TNF-alpha levels. The levels of interleukin-6 (IL), IL-1 beta tested in 24 samples and IL-12 in 30 samples were not significantly increased. Interferon-gamma was present in 10 out of 30 patients with dengue. The data support the concept that the increased level of TNF-alpha is related to the severity of the disease. Soluble TNF receptor p75 was found in most patients but it is unlikely to be related to severity since it was found with an equivalent frequency and levels in 15 patients with dengue fever and another 15 with dengue hemorrhagic fever.
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