Journal
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Volume 1804, Issue 2, Pages 362-373Publisher
ELSEVIER
DOI: 10.1016/j.bbapap.2009.08.002
Keywords
beta-Carbonic anhydrase; Carbon dioxide; Bicarbonate; Catalytic mechanism; Kinetics; Allostery
Categories
Funding
- National Science Foundation [MCB-0741396, CHE-0819686]
- Div Of Molecular and Cellular Bioscience
- Direct For Biological Sciences [0741396] Funding Source: National Science Foundation
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The beta-carbonic anhydrases (beta-CAs) are a diverse but structurally related group of zinc-metalloenzymes found in eubacteria, plant chloroplasts, red and green algae, and in the Archaea. The enzyme catalyzes the rapid interconversion of CO2 and H2O to HCO3- and H+, and is believed to be associated with metabolic enzymes that consume or produce CO2 or HCO3. For many organisms, beta-CA is essential for growth at atmospheric concentrations of CO2- Of the five evolutionarily distinct classes of carbonic anhydrase, beta-CA is the only one known to exhibit allosterism. Here we review the structure and catalytic mechanism of beta-CA including the structural basis for allosteric regulation. (C) 2009 Elsevier B.V. All rights reserved.
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