Journal
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Volume 1804, Issue 5, Pages 1124-1135Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2010.01.020
Keywords
Error-prone DNA polymerase; Translesion synthesis; Lesion bypass; Mutagenic replication
Categories
Funding
- NIH [GM080573]
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM080573] Funding Source: NIH RePORTER
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The Y-family translesion DNA polymerases enable cells to tolerate many forms of DNA damage, yet these enzymes have the potential to create genetic mutations at high rates. Although this polymerase family was defined less than a decade ago, more than 90 structures have already been determined so far. These structures show that the individual family members bypass damage and replicate DNA with either error-free or mutagenic outcomes, depending on the polymerase, the lesion and the sequence context. Here, these structures are reviewed and implications for polymerase function are discussed. (C) 2010 Elsevier B.V. All rights reserved.
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