Journal
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Volume 1804, Issue 3, Pages 520-523Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2009.10.020
Keywords
CDK; DNA-replication; Eukaryotes; Yeast; Multiple phosphorylation
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Funding
- Grants-in-Aid for Scientific Research [20227004] Funding Source: KAKEN
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Cyclin-dependent kinases (CDKs) regulate the progression of the cell cycle in eukaryotes. At the onset of chromosomal DNA replication, CDKs phosphorylate two replication proteins, Sld2 and Sld3, in budding yeast. Phosphorylated Sld2 and Sld3 enhance the formation of complexes with the BRCT (BRCA1 C-terminal)containing replication protein Dpb11. The formation of these complexes is essential and sufficient for the CDK-dependent activation of the initiation of chromosomal DNA replication. Multiple phosphorylation of Sld2 by CDKs fine-tunes the process of complex formation. Here, we discussed the regulation of the initiation step of chromosomal DNA replication via CDK-dependent phosphorylation. (C) 2009 Elsevier B.V. All rights reserved.
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