Journal
NATURE CELL BIOLOGY
Volume 3, Issue 2, Pages E49-E50Publisher
NATURE PUBLISHING GROUP
DOI: 10.1038/35055158
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Recent work has clarified how higher eukaryotic cells 'licence' DNA replication precisely once per cycle. An inhibitor, geminin, prevents replication before mitosis by inhibiting the replication factor Cdt1, Degradation of geminin in anaphase allows Cdt1 to promote binding of MCM proteins, and hence DNA replication.
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