Journal
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Volume 1794, Issue 5, Pages 808-816Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbapap.2008.11.005
Keywords
Outer membrane; Antibiotic; Porin; LPS; Resistance
Categories
Funding
- NIH [AI34905]
- Welch Foundation [E-1597]
- NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [R01AI034905, R29AI034905] Funding Source: NIH RePORTER
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To date most antibiotics are targeted at intracellular processes, and must be able to penetrate the bacterial cell envelope. In particular, the outer membrane of gram-negative bacteria provides a formidable barrier that must be overcome. There are essentially two pathways that antibiotics can take through the outer membrane: a lipid-mediated pathway for hydrophobic antibiotics, and general diffusion porins for hydrophilic antibiotics. The lipid and protein compositions of the outer membrane have a strong impact on the sensitivity of bacteria to many types of antibiotics, and drug resistance involving modifications of these macromolecules is common. This review will describe the molecular mechanisms for permeation of antibiotics through the outer membrane, and the strategies that bacteria have deployed to resist antibiotics by modifications of these pathways. (C) 2008 Elsevier B.V. All rights reserved.
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