Journal
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS
Volume 1794, Issue 5, Pages 738-747Publisher
ELSEVIER
DOI: 10.1016/j.bbapap.2008.11.020
Keywords
Secondary transport; Multidrug transport; Multidrug resistance; MDR; Major facilitator superfamily; MFS
Categories
Funding
- Israel Cancer Research Foundation (ICRF)
- Minerva Foundation
- Israel Science Foundation
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Multidrug transporters are membrane proteins that expel a wide spectrum of cytotoxic compounds from the cell. Through this function, they render cells resistant to multiple drugs. These transporters are found in many different families of transport proteins, of which the largest is the major facilitator superfamily. Multidrug transporters from this family are highly represented in bacteria and studies of them have provided important insight into the mechanism underlying multidrug transport. This review summarizes the work carried out on these interesting proteins and underscores the differences and similarities to other transport systems. (C) 2008 Elsevier B.V. All rights reserved.
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