Journal
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
Volume 441, Issue 5, Pages 674-677Publisher
SPRINGER-VERLAG
DOI: 10.1007/s004240000465
Keywords
nicotinic acid adenine dinucleotide phosphate NAADP; calcium release; ryanodine calcium channel; heart
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Nicotinic acid adenine dinucleotide phosphate (NAADP), a molecule derived from nicotinamide adenine dinucleotide phosphate (NADP(+)), is a recently identified nucleotide that activates Ca2+ release from intracellular stores in invertebrate eggs and in mammalian cells. NAADP could function as an intracellular messenger for mobilizing internal Ca2+ stores, however the targets and nature of NAADP-induced Ca2+ release are unknown. We report here that NAADP (3-10 muM) induces Ca2+ release from rat heart microsomes and that NAADP (1-10 muM) activates single ryanodine receptor/calcium release channels (RyR2) from dog heart incorporated into bilayer lipid membranes. The results indicate that NAADP may play a role in cardiac excitation-contraction coupling by acting on RyR2 channels.
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