Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1843, Issue 3, Pages 603-617Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2013.12.006
Keywords
Matrix metalloproteinase-9; MMP-9; Nitric oxide; Expression; Activation; Regulation
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Funding
- Science Foundation Ireland [SFI-RFP/BMT2781]
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Nitric oxide (NO) and matrix metalloproteinase 9 (MMP-9) levels are found to increase in inflammation states and in cancer, and their levels may be reciprocally modulated. Understanding interactions between NO and MMP-9 is of biological and pharmacological relevance and may prove crucial in designing new therapeutics. The reciprocal interaction between NO and MMP-9 have been studied for nearly twenty years but to our knowledge, are yet to be the subject of a review. This review provides a summary of published data regarding the complex and sometimes contradictory effects of NO on MMP-9. We also analyse molecular mechanisms modulating and mediating NO-MMP-9 interactions. Finally, a potential therapeutic relevance of these interactions is presented. (C) 2013 Elsevier B.V. All rights reserved.
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