Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1843, Issue 8, Pages 1649-1663Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2014.01.035
Keywords
Type 3 secretion; Structural biology; Bacterial secretion; Bacterial pathogenesis
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Funding
- Canadian Institute for Health Research
- Canadian Foundation of Innovation
- British Columbia Knowledge Development Fund
- Natural Sciences and Engineering Research Council of Canada Alexander Graham Bell Canada graduate scholarship
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The Type III Secretion System (T3SS) is a multi-mega Dalton apparatus assembled from more than twenty components and is found in many species of animal and plant bacterial pathogens. The T3SS creates a contiguous channel through the bacterial and host membranes, allowing injection of specialized bacterial effector proteins directly to the host cell. In this review, we discuss our current understanding of T3SS assembly and structure, as well as highlight structurally characterized Salmonella effectors. This article is part of a Special Issue entitled: Protein trafficking and secretion in bacteria. Guest Editors: Anastassios Economou and Ross Dalbey. (C) 2014 Elsevier B.V. All rights reserved.
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