Journal
INFECTION AND IMMUNITY
Volume 69, Issue 2, Pages 1226-1229Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.69.2.1226-1229.2001
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Interleukin-2 (IL-2)/IL-15 receptor beta (IL-15R beta)(-/-) mice were susceptible to infection with avirulent Salmonella enterica subsp. enterica serovar Choleraesuis, whereas IL-2(-/-) mice were resistant. A natural killer cell response was not evident for both types of deficient mice. A Th1 response was detected in IL-2(-/-) but not in IL-2/IL-15R beta (-/-) mice infected with Salmonella, suggesting that IL-2/IL-15R beta signaling is important for the generation of protective Th1 cells.
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