Journal
CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 11, Issue 1, Pages 41-47Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(00)00154-4
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- NCI NIH HHS [CA83182] Funding Source: Medline
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Research during the past couple of years has provided important new information as to how the actin cytoskeleton contributes to growth control in both normal and transformed cells. The cytoskeleton can no longer be viewed as simply a structural framework playing a role in cell shape and motile events such as cell movement, intracellular transport, contractile-ring formation and chromosome movement. More recent experiments show that the cytoskeleton plays a critical role in the regulation of various cellular processes linked to transformation including proliferation, contact inhibition, anchorage-independent cell growth, and apoptosis.
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