Journal
NATURE GENETICS
Volume 27, Issue 2, Pages 156-158Publisher
NATURE AMERICA INC
DOI: 10.1038/84777
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Funding
- NHLBI NIH HHS [R01 HL56028, P01 HL35018, R01 HL63709] Funding Source: Medline
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Spontaneously hypertensive rats (SHR) display several features of the human insulin-resistance syndromes. Cd36 deficiency is genetically linked to insulin resistance in SHR. We show that transgenic expression of Cd36 in SHR ameliorates insulin resistance and lowers serum fatty acids. Our results provide direct evidence that Cd36 deficiency can promote defective insulin action and disordered fatty-acid metabolism in spontaneous hypertension.
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