Journal
JOURNAL OF BIOMEDICAL OPTICS
Volume 20, Issue 6, Pages -Publisher
SPIE-SOC PHOTO-OPTICAL INSTRUMENTATION ENGINEERS
DOI: 10.1117/1.JBO.20.6.065006
Keywords
intravascular photoacoustic imaging; high-speed photoacoustic imaging; spectroscopic photoacoustic technology; atherosclerotic plaque
Funding
- National Natural Science Foundation of China [81427804, 61205203, 61405234, 61475182]
- National Key Basic Research (973) Program of China [2014CB744503, 2015CB755500]
- Shenzhen Science and Technology Innovation [ZDSY-2013-0401165820-357, KQCX-2012-0816155844-962, CXZZ-2012-0617113635-699, JCYJ-2012-0615125857-842]
- Guangdong Innovation Research Team Fund for Low-cost Healthcare Technologies (GIRIF-LCHT)
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Intravascular spectroscopic photoacoustic technology can image atherosclerotic plaque composition with high sensitivity and specificity, which is critical for identifying vulnerable plaques. Here, we designed and engineered a catheter of 0.9 mm in diameter for intravascular photoacoustic (IVPA) imaging, smaller than the critical size of 1 mm required for clinical translation. Further, a quasifocusing photoacoustic excitation scheme was developed for the catheter, producing well-detectable IVPA signals from stents and lipids with a laser energy as low as similar to 30 mu J/pulse. As a result, this design enabled the use of a low-energy, high-repetition rate, ns-pulsed optical parametric oscillator laser for high-speed spectroscopic IVPA imaging at both the 1.2-mu m and 1.7-mu m spectral bands for lipid detection. Specifically, for each wavelength, a 1-kHz IVPA A-line rate was achieved, similar to 100-fold faster than previously reported IVPA systems offering a similar wavelength tuning range. Using the system, spectroscopic IVPA imaging of peri-adventitial adipose tissue from a porcine aorta segment was demonstrated. The significantly improved imaging speed, together with the reduced catheter size and multi-wavelength spectroscopic imaging ability, suggests that the developed high-speed IVPA technology is of great potential to be further translated for in vivo applications. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)
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