Journal
CURRENT OPINION IN CELL BIOLOGY
Volume 13, Issue 1, Pages 61-67Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0955-0674(00)00175-7
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Ankyrins are spectrin-binding proteins that associate via ANK repeats with a variety of ion channels/pumps, calcium release channels and cell adhesion molecules. Recent studies in mice indicate that ankyrins have a physiological role in restricting voltage-gated sodium channels and members of the L1 CAM family of cell adhesion molecules to excitable membranes in the central nervous system and in targeting calcium-release channels to the calcium homeostasis compartment of striated muscle.
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