Are inflammation and immunological hyperactivity needed for filarial parasite development

Immune-dependent growth and development of infectious agents and pathogenesis of disease are increasingly being the development of filarial larvae to adult stage parasites takes place in an ambience of inflammatory T helper cell type 1 cytokines in mammalian hosts, and that susceptibility to filarial infections could be governed by the status of macrophage-derived nitric oxide and host ability to produce antibodies to filarial T-independent (carbohydrate) antigens.