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Cell-cycle-dependent translational control

Journal

CURRENT OPINION IN GENETICS & DEVELOPMENT
Volume 11, Issue 1, Pages 13-18

Publisher

CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-437X(00)00150-7

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Control of translation in eukaryotes occurs mainly at the initiation step. Translation rates in mammals are robust in the G(1) phase of the cell cycle but are low during mitosis. These changes correlate with the activity of several canonical translation initiation factors, which is modulated during the cell cycle to regulate translation.

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