Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1823, Issue 12, Pages 2168-2178Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2012.08.017
Keywords
Akt; Nucleus; Cell survival; Cell proliferation; Tumorigenesis; mRNA export
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Funding
- MinSan 2008
- MIUR PRIN 2008
- MIUR FIRB 2010 [RBAP10447]
- Grants-in-Aid for Scientific Research [24390044] Funding Source: KAKEN
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Akt is a central player in the signal transduction pathways activated in response to many growth factors, hormones, cytokines, and nutrients and is thought to control a myriad of cellular functions including proliferation and survival, autophagy, metabolism, angiogenesis, motility, and exocytosis. Moreover, dysregulated Akt activity is being implicated in the pathogenesis of a growing number of disorders, including cancer. Evidence accumulated over the past 15 years has highlighted the presence of active Akt in the nucleus, where it acts as a fundamental component of key signaling pathways. For example, nuclear Akt counteracts apoptosis through a block of caspase-activated DNase: deoxyribonuclease and inhibition of chromatin condensation, and is also involved in cell cycle progression control, cell differentiation, mRNA: messenger RNA export, DNA repair, and tumorigenesis. In this review, we shall summarize the most relevant findings about nuclear Akt and its functions. (C) 2012 Elsevier B.V. All rights reserved.
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