4.5 Review

Murine mutants in the study of systemic iron metabolism and its disorders: An update on recent advances

Journal

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1823, Issue 9, Pages 1444-1450

Publisher

ELSEVIER
DOI: 10.1016/j.bbamcr.2012.01.011

Keywords

Mouse; Iron; Model; Dietary iron absorption; Hepcidin; Cellular iron metabolism

Funding

  1. NIDDK NIH HHS [K99 DK084122-02, K99 DK084122, K01 DK074410] Funding Source: Medline

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Many past and recent advances in the field of iron metabolism have relied upon the use of mouse models of disease. These models have arisen spontaneously in breeder colonies or have been engineered for global or conditional ablation or overexpression of select genes. Full phenotypic characterization of these models typically involves maintenance on iron-loaded or -deficient diets, treatment with oxidative or hemolytic agents, breeding to other mutant lines or other stresses. In this review, we focus on systemic iron biology and the contributions that mouse model-based studies have made to the field. We have divided the field into three broad areas of research: dietary iron absorption, regulation of hepcidin expression and cellular iron metabolism. For each area, we begin with an overview of the current understanding of key molecular and cellular determinants then discuss recent advances. Finally, we conclude with brief comments on prospects for future study. This article is part of a Special Issue entitled: Cell Biology of Metals. (C) 2012 Elsevier ay. All rights reserved.

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