Journal
CELL STRUCTURE AND FUNCTION
Volume 26, Issue 1, Pages 19-24Publisher
JAPAN SOC CELL BIOLOGY
DOI: 10.1247/csf.26.19
Keywords
vasculogenesis; angiogenesis; transcription factor; ETS
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The ETS family of transcription factors is defined by a conserved DNA-binding ETS domain that forms a winged helix-turn-helix structural motif, This family of transcription factors is involved in a diverse array of biological functions including cellular growth and differentiation, as well as organ development. Among the members of this family, ETS-1, ERG, Fli-1, TEL, and NERF-2 are expressed in endothelial cells and their progenitors, This review will summarize the role of ETS family transcription factors in vascular development and angiogenesis.
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