Receptor activity modifying proteins

Our understandings of G protein-coupled receptor (GPCR) function has recently expanded to encompass novel protein interactions that underlie both cell-surface receptor expression and the exhibited phenotype. The most notable examples are those involving receptor activity modifying proteins (RAMPs). RAMP association with the calcitonin (CT) receptor-like receptor (CRLR) traffics this receptor to the cell surface where individual RAMPs dictate the expression of unique phenotypes. a similar function has been ascribed to RAMP interaction with the CT receptor (CTR) gene product. This review examines our current slate of knowledge of the mechanisms underlying RAMP function. (C) 2001 Elsevier Science Inc. All rights reserved.