Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1813, Issue 7, Pages 1286-1294Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2011.01.009
Keywords
Mitochondria; Ischemia/reperfusion; Cardioprotection; Import; Connexin 43; Protein kinases
Categories
Funding
- German Research Foundation [BO 2955/1-1, He1320/18-1, Schu843/7-2]
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During myocardial ischemia/reperfusion, mitochondria are both a source and a target of injury. In cardioprotective maneuvers such as ischemic and pharmacological pre- and postconditioning mitochondria have a decisive role. Since about 99% of the mitochondrial proteins are encoded in the nucleus, deleterious and protective mitochondrial effects most likely comprise the import of cytosolic proteins. The present review therefore discusses the role of mitochondria in myocardial ischemia/reperfusion injury and protection from it, focusing on some cytosolic proteins, which are translocated into mitochondria before, during, or following ischemia/reperfusion. Both morphological and functional alterations are discussed at the level of the heart, the cardiomyocyte and/or the mitochondrion itself. This article is part of a Special Issue entitled: Mitochondria and Card ioprotection. (C) 2011 Elsevier B.V. All rights reserved.
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