Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 21, Issue 3, Pages 811-813Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.21.3.811-813.2001
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- NIGMS NIH HHS [R01 GM057384, GM57384] Funding Source: Medline
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Mammals express two isoforms of arginase, designated types I and II. Arginase I is a component of the urea cycle, and inherited defects in arginase I have deleterious consequences in humans. In contrast, the physiologic role of arginase II has not been defined, and no deficiencies in arginase II have been identified in humans. Mice with a disruption in the arginase II gene were created to investigate the role of this enzyme. Homozygous arginase II-deficient mice were viable and apparently indistinguishable from wild-type mice, except for an elevated plasma arginine level which indicates that arginase II plays an important role in arginine homeostasis.
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