Journal
TRENDS IN IMMUNOLOGY
Volume 22, Issue 2, Pages 97-101Publisher
ELSEVIER SCI LTD
DOI: 10.1016/S1471-4906(00)01821-4
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Innate immune responses provide the body with its first line of defense against infections. Signals generated by a subset of lymphocytes, including natural killer (NK) cells and natural killer T (NKT) cells, during the early host response might have an additional role in determining the nature of downstream adaptive immune responses. Here, Fu-Dong Shi, Hans-Gustaf Ljunggren and Nora Sarvetnick discuss the role of cellular and soluble components of innate immunity in the development of autoimmune diseases. Some putative pathways leading from innate immunity to autoimmunity are proposed.
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