Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1803, Issue 1, Pages 72-94Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2009.08.006
Keywords
Zinc-binding group; Mechanism-based inhibitor; MMP
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Funding
- University of California, San Diego
- National Institutes of Health [R01 HL00049-01, 5 T32 HL007444-27]
- American Heart Association [0970028N]
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [T32HL007444] Funding Source: NIH RePORTER
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This short review highlights some recent advances in matrix metalloproteinase inhibitor (MMPi) design and development. Three distinct approaches to improved MMP inhibition are discussed: (1) the identification and investigation of novel zinc-binding groups (ZBGs), (2) the study of non-zinc-binding MMPi, and (3) mechanism-based MMPi that form covalent adducts with the protein. Each of these strategies is discussed and their respective advantages and remaining challenges are highlighted. The studies discussed here bode well for the development of ever more selective, potent, and well-tolerated MMPi for treating several important disease pathologies. (C) 2009 Elsevier B.V. All rights reserved.
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