Journal
CURRENT OPINION IN STRUCTURAL BIOLOGY
Volume 11, Issue 1, Pages 47-52Publisher
CURRENT BIOLOGY LTD
DOI: 10.1016/S0959-440X(00)00169-X
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When DNA mismatch repair fairs, the result is a mutator phenotype, which can lead to cancer in humans. Functional repair is dependent on the recognition of mismatches by a dimeric MutS protein, a homodimer in bacteria but a heterodimer in humans. Recent crystal structures of Thermus aquaticus and Escherichia coli MutS have revealed the structural heterodimeric nature of the bacterial proteins and provide new insights into their complicated ATP-dependent repair mechanism.
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