Journal
AMERICAN JOURNAL OF DERMATOPATHOLOGY
Volume 23, Issue 1, Pages 29-35Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00000372-200102000-00005
Keywords
malignant melanoma; metallothionein; metallothionein in cutaneous melanoma
Categories
Ask authors/readers for more resources
Recently, Zelger et al. found that metallothionein expression in melanoma is a useful prognostic indicator in white patients. In this study, we evaluated metallothionein expression in patients with melanoma as a prognostic indicator. We studied the tumors of 44 patients with cutaneous melanoma seen in our clinic from July 1988 to August 1998. Twenty-five neoplasms were metallothionein-positive, and 19 were metallothionein-negative. Only 9 (37.5%) of 24 cases of level I through III melanoma were positive for metallothionein, but 16 (80%) of 20 level IV and V cases were positive. Eight (40%) of 20 cases of thin melanoma (thickness: 1.5 mm) were metallothionein-positive, and 17 (70.8%) of 24 cases of thick melanoma (thickness: >1.5 mm) were metallothionein-positive. These results indicate a strong correlation of metallothionein expression with the level of invasion and tumor thickness in melanoma. The survival distribution function curve (Kaplan-Meier) for metallothionein expression showed a much better survival rate in the metallothionein-negative group than in the metallothionein-positive group.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available