Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1793, Issue 7, Pages 1115-1127Publisher
ELSEVIER
DOI: 10.1016/j.bbamcr.2009.03.004
Keywords
Syk; B cell activation; Antigen receptor; Protein-tyrosine kinase; Protein phosphorylation; Signal transduction
Categories
Funding
- National Cancer Institute [CA037372]
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The B cell receptor (BCR) transduces antigen binding into alterations in the activity of intracellular signaling pathways through its ability to recruit and activate the cytoplasmic protein-tyrosine kinase Syk. The recruitment of Syk to the receptor, its activation and its subsequent interactions with downstream effectors are all regulated by its phosphorylation on tyrosine. This review discusses our current understanding of how this phosphorylation regulates the activity of Syk and its participation in signaling through the BCR. (C) 2009 Elsevier B.V. All rights reserved.
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