Journal
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
Volume 1793, Issue 1, Pages 33-41Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbamcr.2008.06.021
Keywords
Mitochondria; Protein translocases; Protein transport; Protein sorting
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Funding
- Deutsche Forchungsgemeinschaft [SFB 594]
- Fonds der Chemischen Industrie
- German-Israeli Foundation
- German-Israeli Project Cooperation [DIP F.5.1]
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Mitochondria are essential organelles of the eukaryotic cells that are made by expansion and division of preexisting mitochondria. The majority of their protein constituents are synthesized in the cytosol. They are transported into and put together within the organelle. This complex process is facilitated by several protein translocases. Here we summarize current knowledge on these sophisticated molecular machines that mediate recognition, transport across membranes and intramitochondrial sorting of many hundreds of mitochondrial proteins. (C) 2008 Elsevier B.V. All rights reserved.
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